Senior Chemist in Springfield, MO at AMRI

Date Posted: 12/19/2019

Job Snapshot

Job Description

Senior Chemist in Springfield, MO

AMRI provides global contract research and manufacturing including Quality Control services to the pharmaceutical and biotechnology industries.   

Senior Chemist API is an integral part of the AMRI team, contributing to our success by providing technical development and support for manufacturing, chemical research and development, QC and Purchasing.   Also, by providing development and support for the introduction of new products and to support, optimize and refine methods of operation and processes for existing products used in cGMP manufacturing of pharmaceuticals and pharmaceutical intermediates. 

Join our talented workforce, where a commitment to excellence and a customer focused attitude is everything. We pursue excellence because our work has the power to improve patients’ lives with the pharmaceuticals we develop and manufacture.

In this role, you will:   

  • Execute contract projects independently.  Document and report results of development and experimentation to Department Head.  
  • Development and evaluation of new chemical process technology and methods.  Introduce, optimize, validate and support new processes into the laboratory, kilo lab, plant, or pilot plant facility.
  • Develop strategies to optimize production processes with respect to yield, quality, throughput, cost and minimization of waste streams.  Implement programs as required to optimize processes and resolve issues.
  • Prepare laboratory, kilo-scale and pilot-scale quantities of materials.
  • Provide detailed instruction and/or training to site employees.
  • Prepare and evaluate process descriptions, procedures, process flow diagrams, process summaries, throughput, mass balance and chemical process information, raw materials and process economics.
  • Write detailed reports on work and activities including periodic reviews of work and special work summaries such as validation reports, process summaries, etc., as required.
  • Search and review scientific literature as required to plan and conduct sound and reasonable experimental strategies in a concise and expeditious manner.
  • Ability to supervise a project team and directly communicate with customers in consultation with internal customers, and suppliers, to address technical issues.
  • Regularly communicate and present results of work performed in a clear, concise and accurate manner.
  • Prepare and review written instructions (batch sheets, SOP’s etc.) to ensure that the products are made safely and under current good manufacturing practices.
  • Maintain complete and up to date files for existing projects.
  • Review proposed changes from a safety, practicality, feasibility, and GMP perspective following “Management of Change” protocol.
  • Perform laboratory experiments that are scientifically sound and generate valid data for making technologically sound decisions.  Laboratory technique must be reproducible with no inherent bias.
  • Conduct all job responsibilities in a manner consistent with all applicable safety and environmental laws and regulations, company policies and procedures, site chemical hygiene plan, regulations, and commit to continuously improve safety and environmental performance.
  • Keep the R&D Manager up to date and informed of any significant results, events, deviations from expected results, or work being conducted or envisioned that may impact the business. 
  • Perform statistical evaluations of laboratory and plant data to determine relevance and applicability of data.
  • Work with Analytical group to assist in development of analytical methodology or standards for new or revised processes.
Secondary Responsibilities: 

  • Assist Engineering and/or maintenance with identification of equipment requirements (i.e., material of construction, etc.)
  • Participate in monthly inspection of laboratory eyewashes, safety showers and/or fire extinguishers to ensure their operational status.
  • Store laboratory chemicals properly and in accordance with the chemical hygiene plan.
  • Participate as a chemistry subject matter expert in Process Hazards Analysis of processes to assure safe manufacturing process design.
  • Maintain a high level of knowledge of current scientific literature and to attend relevant internal and external technical meetings and conferences, as required.

Job Requirements

Required:
  • PhD Organic chemistry with 5 years or more relevant experience.  

  • Experience working with FDA, EPA, and OSHA regulated pharmaceuticals manufacturing requirements.  

  • A broad knowledge of modern synthetic organic methodologies and experience in multi-step synthesis of laboratory, kilo-scale, pilot-scale and process scale-up to commercial quantities of materials.  

  • Effective communication skills for preparation of written technical reports, presentations, SOP’s, batch sheet instructions and effective participation in meetings, problem solving exercises, etc.

  • Ability to use and interpret data from modern analytical equipment such as NMR, HPLC, IR, etc. 

Work Environment

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.  Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

While performing the duties of this job the employee is regularly required to work in a normal office/lab/pilot plant environment and is regularly required to enter the production area of a typical manufacturing facility which has moving mechanical parts, and may have fumes or airborne particles, extreme heat, wet and /or humid conditions, low levels of toxic or caustic chemicals, and outside weather conditions.  The noise level in the environment is usually moderate.


Shift:  

An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. If you have any difficulty using our online application system due to a disability or believe you need a reasonable accommodation to search for a job opening or submit an application, you may use the alternative email address jobs@amriglobal.com to contact us about your interest in employment or you may call us at 518.512.2000.

Please note: The above-referred email address and telephone number are dedicated communication lines designed exclusively to assist job seekers whose disability prevents them from being able to apply online. Messages left for other purposes will not receive a response.

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AMRI is committed to providing equal opportunity to all job seekers including qualified individuals with disabilities. If you have any difficulty using our online application system due to a disability or believe you need a reasonable accommodation to search for a job opening or submit an application, you may use the alternative email address jobs@amriglobal.com to contact us about your interest in employment or you may call us at 518.512.2000.

Please note: The above referenced email address and telephone number are dedicated communication lines designed exclusively to assist job seekers whose disability prevents them from being able to apply online. Messages left for other purposes will not receive a response.